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KMID : 0366919940060010001
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Sungkyun Pharmceutical Journal
1994 Volume.6 No. 1 p.1 ~ p.9
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Effects of carbachol on nitric oxide synthase activies and methylated arginine contents in chicken pancreatic tissues
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Hong Seong-Ryeul
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Abstract
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The role of nitric oxide (NO) in the regulation of exocrine secretion was investigated in chicken pancreatic tissues. Nitric oxide synthase (NOS) in the pancreatic tissues were Ca^2+-dependent form. Treatment of tissue with L-arginine (10 mM) or carbachol (10^-5 M) showed the increase of pancreatic exocrine secretion, but that of D-arginine (10 mM) did not. ^3H-citrulline formation, cyclic GMP level and methyl arginine contents in the homogenates of pancreatic tissues treated with carbachol were not affected. Although the action mechanism of NO in the pancreatic tissues remains unknown, NO apparently participates significantly in the overall control of pancreatic secretory function.
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